I'm happy to share the blogs on this page which are all my own work, originally posted on LinkedIn. I've moved them here to make it easier for everyone to find and read them in one place. Each piece is a snapshot of my thoughts and feelings when I wrote it.
2024
I spent a lot of time this week talking to cultivated meat ambassadors, cell-based meat (CBM) business founders, and even politicians about the now and the future of this industry.
One thing that regularly comes up is the topic of the evolution of CBM. And to that regard, I found a really great article that is still more than relevant today, by Jessica Scott-Reid in Corporate Knights: Advocates of lab-grown meat poke holes in claim it's bad for the environment
To avoid revealing too many details from Jessica's piece, two quotes particularly stand out, shedding light on our collective journey. Liz Specht draws an analogy, suggesting that evaluating the environmental impact of solar panels should not be based on outdated 1980s production methods, just as we shouldn't judge the potential of cultivated meat by the standards of current R&D-scale processes.
Similarly, Bruce Friedrich, speaking at the Animal and Vegan Advocacy Summit in Los Angeles, highlighted the flawed logic of doubting the future infrastructure for innovations, likening it to early scepticism around electric vehicles due to the then-lack of charging stations. This, he argues, overlooks the natural progression of innovation.
A recent UC Davis study raises questions about the environmental impact of cell-cultured meat, suggesting it might be more significant than that of traditional meat. This study, still under review, is built on assumptions like the use of pharmaceutical-grade media in cell cultivation, sparking a debate about its accuracy. Could these assumptions be a call to arms for researchers, the industry, and environmentalists to work together on making cell-based meat more eco-friendly?
As I said, this tech is still evolving. It's just getting off the ground, and its current environmental footprint is not set in stone but a stepping stone to something far more efficient than animal protein. At the same time, being open about the challenges and potential of cell-cultured meat helps build public trust and understanding.
Have a read of WIRED's Matt Reynolds: The Murky Campaign to Discredit Lab-Grown Meat
If you ever wanted to see the face of fake news, look no further for the Center for Environment and Welfare (CEW), who, in addition to an important-sounding name, manufactured exaggerated claims about cell-based meats (CBM). While regulatory bodies across the globe, including those in the US, Singapore, and Australia, have thoroughly assessed CBM and found it perfectly safe for consumption, CEW compares CBM cells to tumour cells aimed at mongering fear. The cells' ability to replicate indefinitely in a controlled environment is a technical feature, not a health threat.
Their claims hold as much water as hot oil, but wait, what about the environmental argument? CEW's narrative around CBM's carbon footprint cherry-picked studies to paint an alarming picture, conveniently ignoring the bulk of research that showcases CBM's potential for drastically reducing environmental impacts compared to traditional livestock farming. The sustainability argument for CBM is robust! It undercuts fears with facts about resource efficiency and lower emissions.
The approach taken by CEW seems mainly aimed at exploiting misunderstandings and unfounded fears, but why? Their selective use of information and scare tactics is more about preserving status quo interests than promoting an informed public debate. Again why?
The underlying motives of CEW's campaign should be a red flag. Are there vested interests at play, more concerned with protecting hidebound, unethical, and inefficient agricultural practices? The push against CBM feels a lot like a distraction from consumer choice, given that CBM is about offering alternatives that align with modern values and environmental needs.
In 2023, Science|Business highlighted the need for increased funding from the European Union for alternatives to conventional meat. While the EU wants to meet its sustainability goals, it has to consider diversifying protein sources through research in non-traditional proteins like lab-grown meat and plant-based options.
SB notes the low investment in alternative protein research despite the potential. Policymakers must leverage partnerships and public financial mechanisms, which [still] largely rely on private investment.
I'd think infrastructure support for startups and engagement with traditional food processors are essential for scaling production and enhancing consumer acceptance. Still, there seems to be a blind spot that leaves novel food startups vulnerable. What measures are being considered to ensure regulatory procedures support developing and commercialising alternative proteins to keep pace with global competitors?
Call for more EU funding for meat alternatives
Now, in 2024, Science|Business reports that Europe's innovative food sector is witnessing challenges with the EU's novel food approval process. This process is considered less efficient than those of other regions, such as Singapore and the US.
"Europe is home to some of the world’s most innovative food companies creating alternative proteins, but many are choosing to launch their products first in the US or Singapore."
Companies like Meatable and Formo, as well as innovators in France and Italy, want to launch their products outside Europe due to faster and clearer approval processes in Singapore and the US. According to SB The European Food Safety Authority (EFSA) is reported to be understaffed, leading to delays in the review process, despite offering pre-submission advice and engaging in dialogue with stakeholders.
Industry alliances and companies are advocating for more resources for EFSA, clearer guidelines, and support in the application process. The question remains, how will the EU intend to address the current challenges related to the commercial scaling of innovative food technologies to prevent further migration of Europe's food tech companies to more accommodating regulatory environments?
EU novel food start-ups call for more clarity in approval process
Who is the EFSA?
The European Food Safety Authority (EFSA) conducts thorough assessments to ensure the safety of foods created through cell culture technologies, such as lab-grown meat and dairy products made from cells or microorganisms. These modern methods, which include techniques like tissue engineering and precision fermentation, have evolved from their origins in healthcare to now play a role in food production. The EFSA's methodical process includes input from experts, companies specialising in these technologies, and consumer representatives, making sure that the evaluation of these new types of food meets the highest scientific and risk assessment standards.
EFSA: The safety of cell culture-derived food – ready for scientific evaluation
In the European Union, the oversight of these foods is a collaborative effort between the European Commission and the individual Member States, with a strong focus on protecting consumers. This effort also takes into account the broader impacts on society and the environment, supporting the EU's aim to create a sustainable food system from production to consumption.
How consumers feel about foods derived from cell cultures depends on a set of qualities that represent their views on how natural these foods are perceived through their taste but also their cost. Addressing any concerns people might have and educating them about the environmental advantages of these technologies are crucial steps towards gaining public acceptance. Clear, honest and transparent communication about their safety, backed by strict, openly accessible and understandable evaluations and regulatory supervision, is absolutely... irrefutable.
European Parliament: What if all our meat were grown in a lab?
The environmental impact of livestock production cannot be understated. It's a concern because of greenhouse gas emissions, its role in land degradation, and chemical fertiliser and methane pollution. This form of production demands considerable resources, including vast amounts of water and land, contributing heavily to deforestation, the loss of biodiversity, and water pollution.
The anticipated global food production needs to rise by 2050, driven by population growth and increasing meat consumption, especially in developing countries. Cell-based meat (CBM) meat offers a promising solution. By cultivating meat in controlled environments through stem cell technology, we can reduce the environmental footprint of livestock farming.
The transition towards lab-grown meat could affect the EU's agricultural sector, impacting economies, employment, and the communities that rely on traditional farming. These impacts must be understood to ensure the sector is prepared for change, supporting farmers and communities in this transition towards a sustainable food system within the EU.
• The EU should allocate funds for R&D to improve efficiency, scalability, and cost-effectiveness. This could involve supporting startups and established companies, universities and research institutions.
• Particularly the EU must support rural development projects that provide alternative income sources for communities affected by the transition.
The adoption of CBM hinges the health benefits and public acceptance. It promises to lower saturated fat intake, eliminate antibiotic use, and reduce disease transmission risks. Simultaneously, educating the public and addressing misconceptions are vital to changing dietary habits and ensuring acceptance. Embracing lab-grown meat involves merging health advantages with efforts to inform consumers.
Policy-making will be the most influencial tool to address the marketing and corporate affairs gaps faced by CBM startups pegged against animal agriculture. The EU can aid this shift by enacting policies that ensure a level playing field. Measures should include clear regulatory standards for the safety and quality of lab-grown meat, streamlined product approval processes, financial incentives like grants and tax breaks for innovation, and government-funded public awareness campaigns to highlight CBM's environmental and ethical advantages.
The Czech government granted nearly €200,000 to Mewery on January 26, 2024. This funding, facilitated by the CzechInvest Technological Incubator, supports Mewery's research into cultivated pork using microalgae. I recently reviewed the process of using microalgae in a post if you want to read up on that research.
The investment aims to improve the company's technological platform, preparing it for expansion (Presumably improving computing power and implementing AI solutions to optimise processes).
Mewery's work focuses on developing a sustainable and ethical alternative to traditional pork, potentially reducing environmental impacts. They have developed what is described as the "first-ever" cultivated burger made from pork and microalgae cells. This development is part of a broad initiative to create slaughter-free pork alternatives that are sustainable and ethical and capable of dramatically reducing the environmental impact associated with traditional pork production.
Source: Czech Government Supports Mewery with €200K Grant to Cultivate Pork
When we look at how food is produced worldwide, there's a glaring inefficiency in how plant-based feeds are turned into animal protein. This is particularly true for beef, where just a tiny part of the feed's energy and protein ends up as beef that people can eat. Essentially, we're using a lot of potential human food to produce a much smaller amount of food from animals.
Despite this, the huge wastage and unnatural elements of animal farming tend to be overlooked.
Meanwhile, the concept of lab-grown meat, which is made by cultivating cells in a controlled setting, often faces doubt and criticism. This situation highlights the urgent need to think differently about how we produce food, with a focus on new methods that are both sustainable and efficient.
Source: Animals Are The Most Inefficient Way Of Making Protein
Recycling, the Circular Economy, and sustainability were also hot topics at the second Annual Meat Evolution Leaders Summit hashtag#MEVO in Barcelona last week, where you might have met BOB FoodTech.
Conversations about the price and ecological effects of lab-grown meat often point out its steep initial expenses and concerns over its carbon footprint, noting that a single lab-grown burger cost about $300,000 back in 2010. These discussions rarely touch upon the inefficiencies of conventional livestock farming.
This industry is characterised by a significant wastage of resources, with the food consumed by just beef cattle having the potential to feed 10 billion people within an 18-month time horizon (the typical lifespan of a cow), not overlooking the resources used by chickens and pigs. Converting this food into energy results in a considerable loss, with no effective way to recycle this energy back into producing food.
In contrast, producing meat from cells is leading the way in finding sustainable solutions to these issues.
Meet BOB (your friendly "Bio Optimal Binding" solution), a breakthrough in reusing the growth medium crucial for making lab-grown meat and seafood both environmentally friendly and affordable. This innovation tackles the main issue faced by producers in this field: the prohibitive cost of production, largely due to the growth medium, which accounts for up to 95% of the production costs. The medium is vital for supporting cell development by providing necessary nutrients and growth factors, but its reuse has been limited by the build-up of harmful metabolites.
BOB's technology involves encapsulated RNA structures designed to capture and eliminate these harmful molecules, providing a revolutionary way to purify the medium, allowing for its reuse and greatly lowering the costs associated with producing lab-grown meat.
Source: Bio Optimal Binding
Here are two images of technology used to produce synthetically made food products. Can you guess which one is beer and which one is cell-cultured meat?
Actually, I apologise this is a trick question because neither is truly synthetic. Both brewing beer and cultivating meat involve leveraging natural biological processes—fermentation in beer production and cellular growth for cultivated meat. These processes occur in nature, with fermentation being a spontaneous activity where yeasts convert sugars to alcohol and carbon dioxide, and cellular growth being fundamental to organism development. The human intervention in both cases—selecting ingredients and controlling conditions for beer brewing, and providing a nutrient-rich medium for cell cultivation—aims to guide and optimise these natural processes for specific outcomes. While brewing beer has been practised for millennia, cultivating meat is a contemporary innovation, yet both fundamentally rely on understanding and harnessing biological activities. Thus, despite their distinct end products and technological complexities, both processes share a foundation in natural biological phenomena, refined and directed by human ingenuity.
Islamic scholars from around the world have put out a few statements over the past year, including one in January 2024, in which they commend the practice of producing cultivated meat, acknowledging it as halal.
Seeing cell-based meat as halal is a great mix of old traditions and new tech. It means we can keep our food habits up to date with the latest science without breaking religious rules. This method provides better control over how food is made, making sure it's clean and right according to halal laws. It's also good for the planet and the animals. Plus, it opens up new ways to make sure everyone has enough meat, in a kinder, more efficient way. This fits well with Islamic teachings about caring for others and the Earth.
In my view, there are still some open questions: At what point does a cell line, cultivated far from its origin, cease to be an extension of the host from which it was derived? Is the identity of a cell defined by its genetic lineage or by the context in which it exists and functions? Can the process of replication and differentiation sever the ontological ties between a cell line and its original source? How do we navigate the ethical terrain when the life of a cell transcends its biological origins to become something entirely new?
I'm sure I'm not the only one who enjoys a good coffee in the morning? But I might have to throw my grinder out soon... 🙃
Pluri Inc., a leading biotech company I have written about a few times, announced its cell-based coffee launch. I know right 😯! Perfect coffee.
Why is it even necessary? are we going too far now? No because it is a direct countermeasure to the looming global coffee crisis, driven by the effects of global warming. The traditional coffee industry, worth over $130 billion, is under threat as viable land for coffee cultivation is expected to diminish by up to 50% by 2050(1)(2). Pluri's solution, developed using its proprietary 3D technology platform under the new business vertical PluriAgtech, is designed to produce high-quality coffee sustainably on a mass scale.
They're looking at cutting down on water use and the need for large farming areas. This could help address deforestation, fluctuating prices, and the high carbon footprint linked to traditional coffee farming. With the demand for coffee expected to rise sharply, Pluri's method can ease the strain on the environment.
Michal Ogolnik, who has over 20 years of executive management experience in pharma and energy, is leading this project and under her direction, Pluri is setting up a separate subsidiary focused on developing new products and technologies for the coffee industry. Yaky Yanay, the CEO of Pluri, is confident about the role of cell technology in making agriculture and food production more efficient and environmentally friendly. This move is part of Pluri's wider goal to use their technology in different sectors to promote well-being and sustainability. It looks like Pluri could really make a mark in the coffee industry and agricultural technology as a whole.
You guys are probably sick of hearing about the challenges of CBM 😂 but here we are. Cultivated meat innovation is a long, drawn-out process unlikely to change the world with a bang. Innovation takes time, even with advancements in AI and Quantum technology.
Every now and then, however, there are breakthroughs in food technology. This time, a team of researchers from Beijing, China, tackled the challenge of sustainable meat production by developing cultured meat using porcine pre-gastrulation epiblast stem cells (pgEpiSCs). If you read that as prgaebpiglablacells, that's fine; stay with me. PgEpiSCs [feel free to call them pig cells] are derived from the early developmental stage of pig embryos, specifically from the epiblast layer. These pluripotent cells can develop into almost any cell type in the pig's body. In cultured meat production, pgEpiSCs are vital as they can be converted into muscle cells, offering a sustainable alternative to conventional meat production. pgEpiSCs offer an advantage over other stem cells due to their ability to be cultured for extended periods without losing their differentiation potential, making them suitable for large-scale cultured meat production.
I can honestly advise anyone interested in
#cultivatedmeat to read this study because it is so interesting and comprehensive! The study addresses the challenge of finding stable cell lines that can be expanded over time for CM production. As mentioned, past efforts used various muscle stem cells (MuSCs), which have limitations in long-term in vitro expansion. They address developing a culture medium without serum (a component often derived from animals). It covers scaffold construction that supports cell growth and is entirely free of animal products.
The paper discusses the successful use of pgEpiSCs, which can be stably passaged in vitro, maintaining their genomic stability without significant DNA damage or cancerous characteristics in great detail. The research also includes an in-depth analysis of both the transcriptomic (gene expression) and metabolic levels to confirm the accuracy of the differentiation process.
The team discusses future challenges in cultured meat production using pgEpiSCs, which involve simplifying the complex differentiation process for better industrial scalability and reducing high production costs through biosynthesis and standardising inputs like serum substitutes and growth factors. The study also emphasises strict adherence to ethical standards in animal treatment and provides detailed methodologies for cell culture and scaffold preparation, aligning with institutional guidelines.
Source: https://www.nature.com/articles/s41467-023-44001-8